Attenuation of carbon tetrachloride - induced hepatic fi brosis by glycine , vitamin E , and vitamin

Liver fibrosis is a reversible wound-healing process that occurs in almost all patients with chronic liver diseases. The sustained liver injuries in chronic liver diseases cause multiple cells and cytokines act in a dynamic and interactive way to comprise the mechanisms of fibrogenesis. Though early stage of fibrosis is usually silent in symptoms; progression to cirrhosis may cause almost all kinds of hepatic complications, including portal hypertension, ascites, hepatic encephalopathy, and impaired metabolic disturbance, therefore, it is largely responsible for mortality of hepatopathy [1,2]. Meanwhile, liver fibrogenesis is orchestrated by a heterogeneous population of profibrogenic myofibroblasts, the majority originating from hepatic stellate cells (HSCs), following a process termed “activation”. Other sources of fibrogenic cells have recently been implicated, including portal fibroblasts and cells derived from the bone marrow [3].